Leonardo G. Mancillas-Adame – Bio Profesional

LaSalud.mx .- Academic Clinical Endocrinologist with advanced fellowships in diabetes and obesity, researcher and pharma experienced. 


  • M.D., Universidad Autónoma de Nuevo Leon
  • Residence, Internal Medicine, National Institute of Medical Sciences and Nutrition
  • Fellowship, Endocrinology, National institute of Medical Sciences and Nutrition 
  • Advanced Fellowship, Diabetes and Metabolism, National Institute of
  • Medical Sciences and Nutrition
  • Advanced Fellowship, Obesity and Eating Behavior, National Institute of
  • Medical Sciences and Nutrition
  • PhD Universidad Autónoma de Nuevo León, ongoing. 


  • Sep 2009-Feb 2012, Advisor, Provincial Ministry of Health, Nuevo Leon, Mexico 
  • Sep 2009-Feb 2012, Co-chair, Provincial Program to Prevent Obesity,
  • Nuevo Leon, Mexico 
  • Member of the American Diabetes Association, Canadian Diabetes Association, Mexican Society of Endocrinology and Nutrition.
  • Overseas Fellow, Royal Society of Medicine, London (2015-Present). 


  1. J.G. Gonzalez-Gonzalez, L.G. Mancillas-Adame, F.J. Lavalle-Gonzalez, and J.Z. Villarreal-Perez, Transient pituitary elargement and dysfunction due to lymphocytic hypophysitis. The Endocrinologist, 1997. 357-363.
  2. J.G. González-González, N.E. de la Garza-Hernández, L.G. Mancillas-Adame, J. Montes-Villarreal & J.Z. Villarreal-Pérez. A high-sensitivity test in the assessment of adrenocortical insufficiency: 10 mcg vs 250 mcg cosyntropin dose assessment of adrenocortical insufficiency. Journal of Endocrinology. Nov 1998 Volume 159, No 2, 275-280.
  3. Juan F. Gallegos-Orozco, Leonardo Mancillas-Adame, Candelario Soberanes Cerino, Juan Bobadilla and Luis F. Uscanga.  Ampullary Neuroendocrine Carcinoma. American Journal of Gastroenterology. Volumen 95, – 2573, September 2000.
  4. Mancillas-Adame LG. Gomez Perez FJ. Rull-Rodrigo JA. Diagnóstico y Clasificación de la Diabetes Mellitus. (Diabetes Mellitus, Diagnosis and Classification)Revista de la Sociedad Mexicana de Nutrición y Endocrinología. Rev Endocrinol Nutr 2002; 10 (2).
  5. Mancillas-Adame L, Morales-González G. Tratamiento Farmacológico para Obesidad. Gac Med Mex. 2004 Jul-Ago; 140 Supl 2: S91-5.
  6. he DREAM Trial investigators, rationale, Design and Recruitment characteristics of a large, sample international trial of Diabetes prevention: the DREAM trial, Diabetología, volume 47, Issue 9, Sep 2004, 1519-1527, DOI 10.1007/s00125-004-1485-5, URLhttp://dx.doi.org/10.1007/s00125-004-1485-5
  7. Guillermo J. Ruiz Delgado,Danitza Fernandez Lara, Sergio Herrero Herrera, Leonardo Mancillas Adame, Eucario León Rodríguez, Carmen Zavala García. Hemocromatosis hereditaria: Informe de un caso y breve revisión de la bibliografía. Med Int Mex 2005; 21:156-60.
  8. Vázquez-Velázquez V, Mancillas-Adame LG, García-García E. Anxiety, depresión and quality of life in obese women with and without binge eating disorder. Obes Rev 2005; 6 (Supl. 1): 111.
  9. Mancillas Adame LG. Vázquez-Velázquez V, Manjarrez- Martínez I, SorianoCortés R, Zamora/ Barrón M, Zamudio-Villarreal F, García-García E. Does the oral glucosa tolerante test changes the glucosa tolerante status in obese patients with normal fasting glucose? Obes Rev 2005;6 (Suppl. 1):137.
  10. J.G. González-González, L.G. Mancillas-Adame, M. Fernández-Reyes, M. Gómez Flores,F.J. Lavalle González, J.Ocampo-Candiani, J.Z. Villarreal Pérez. Androgenetic alopecia and insulin resistance in young men. Clinical Endocrinology(2009), 71,494-499.
  11. L.G.Mancillas- Adame, J.G. González-González,J.O. Jáquez-Quintana, M.A. Cardoza-Torres, A. de la Fuente- García. Diabetic myonecrosis in a patient with hepatic cirrosis: a case report and review of the literature. Journal of medical case reports, 2009, 3:9305 doc.10.1186/1752-1947-3-9305.
  12. J.G.González-González, L.G.Mancillas-Adame,F.J.Lavalle-González, J.Montes-Villarreal, P.A.García-Hernandez, S. Zuñiga-Guajardo, J.G.Ayala Villarreal, J.Z. Villarreal-Perez. Aptitud de los alumnos de pregrado de la carrera de Medicina ante dos modelos de evaluación: El caso de Endocrinología. (Aptitude among undergraduate students of the medical career facing two evaluation models: The case of the Endocrinology course.) Medina Universitaria 2010; 12(47); 106-111.
  13. C.Treviño-Garza, F.J.Bosques-Padilla,C.M.Estrada-Zuñiga,L.G.Mancillas- Adame, J.Z.Villarreal-González, V.Abrego-Moya, Typical Leptin Fall in Mitigated by Breaslfeeding in Female Infants. Arch Med Res. 2010 Jul;41(5):373-7. doi: 10.1016/j.arcmed.2010.08.001.
  14. Treviño-Garza C, Mancillas-Adame L, Villarreal-Pérez JZ, De la O-Cavazos ME, Estrada-Zúñiga CM, Bosques-Padilla FJ, Argente J. Association between umbilical cord leptin and weight gain according to feeding type in the early postnatal period, a brief report. Rev Invest Clin. 2012 Nov-Dec;64 (6 Pt 2):615-9
  15. Aschner P, Chan J, Owens DR, Picard S, Wang E, Dain MP, Pilorget V, Echtay A, Fonseca V; EASIE investigators (listed here). Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial. Lancet. 2012 Jun 16;379(9833):2262-9. doi: 10.1016/S0140-6736(12)60439-5. Epub 2012 Jun 9.
  16. Rodríguez-Gutiérrez R, Lavalle-González FJ, Martínez-Garza LE, LanderosOlvera E, López-Alvarenga JC, Torres-Sepúlveda MR, González-González JG, Mancillas-Adame LG, Salazar-Gonzalez B, Villarreal-Pérez JZ. Impact of an exercise program on acylcarnitines in obesity: a prospective controlled study. J Int Soc Sports Nutr. 2012 May 10;9(1):22. doi: 10.1186/1550-2783-9-22.
  17. Rodríguez-Quintanilla KA, Lavalle-González FJ, Mancillas-Adame LG, Zapata-Garrido AJ, Villarreal-Pérez JZ, Tamez-Pérez HE. Continuous glucose monitoring in acute coronary syndrome. Arch Cardiol Mex. 2013 OctDec;83(4):237-43. doi: 10.1016/j.acmx.2013.08.001. Epub 2013 Nov 25.
  18. de la Fuente-García A, Gómez-Flores M, Mancillas-Adame L, Ocampo-Candiani J, Welsh-Lozano O, Pérez JZ, González-González JG, LavalleGonzález F. Role of the ACTH test and estimation of a safe dose for high potency steroids in vitiligo: A prospective randomized study. Indian Dermatol Online J. 2014 Apr;5(2):117-21. doi: 10.4103/2229-5178.131071.
  19. Kuritzky L, Umpierrez G, Ekoé JM , Mancillas-Adame L, Fernandez Lando L. Safety and Efficacy of Dulaglutide, a Once Weekly GLP-1 Receptor Agonist, for the Management of Type 2 Diabetes. Postgrad Med. 2014 Oct;126(6):60-72. doi: 10.3810/pgm.2014.10.2821
  20. Rodríguez-Gutiérrez R, Villarreal-Pérez JZ, Morales-Martinez FA, RodríguezGuajardo R, González-Saldivar G, Mancillas-Adame LG, Alvarez-Villalobos NA, Lavalle-Gonzalez FJ, González-González JG. Ovarian and adrenal androgens and their link to high human chorionic gonadotropinlevels: a prospective controlled study. Int J Endocrinol. 2014;2014:191247. doi: 10.1155/2014/191247
  21. Treviño-Garza C(1), Mancillas-Adame L, Estrada-Zúñiga CM, VillarrealPérez JZ, Villarreal-Martinez L, De la O-Cavazos ME. Measurement of Leptin by RIA Versus MIA in a Population of Healthy Newborns. J Clin Lab Anal. 2015 Mar 26. doi: 10.1002/jcla.21845. 
  22. Velez-Viveros CA, González-González JG, Rodríguez-Flores M, MancillasAdame LG. Comparing Apples to Apples. Is it Fair to Compare Suboptimal Doses of Medications to Surgery? Obes Surg. 2018 Mar;28(3):850-851. doi:10.1007/s11695-017-3082-y. 
  23. Portillo-Sanchez P, Gonzalez-Velazquez C, Mancillas-Adame L. Sample Size Matters When Drawing Conclusions on Alternate-Day Fasting Diet. JAMA Intern      Med.   2017   Nov     1;177(11):1700-1701. doi:10.1001/jamainternmed.2017.5850. 
  24. Treviño-Garza C, Estrada-Zúñiga CM, Mancillas-Adame L, VillarrealMartínez L, Villarreal-Pérez JZ, Rodríguez-Balderrama I, Montes-Tapia FF, de la O Cavazos ME. Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns. J Clin Res Pediatr Endocrinol. 2016 Sep 1;8(3):321-4. doi: 10.4274/jcrpe.2693. Epub 2016 Apr 18.
  25. Estrada-Zúñiga CM, de la O-Cavazos ME, Mancillas-Adame L, LavalleGonzálezFJ, Lavalle-Cantú AL, Villarreal-Pérez JZ, Treviño-Garza C. Are cord blood visfatin concentrations different depending on birth weight category? Endocrinol Diabetes Nutr. 2019 Jan;66(1):35-40. English, Spanish. doi:10.1016/j.endinu.2018.07.004. Epub 2018 Oct 16. PMID: 30341033.
  26. Pollock RF, Norrbacka K, Cameron C, Mancillas-Adame L, Jeddi M. A cost- utility analysis of dulaglutide versus insulin glargine as third-line therapy for Type 2 diabetes in Canada. J Comp Eff Res. 2019 Mar;8(4):229-240. doi: 10.2217/cer2018-0073. Epub 2019 Jan 15. PMID: 30644328.
  27. Rodriguez-Gutierrez R, Mancillas-Adame LG, Rodríguez-Tamez G, Diaz Gonzalez-Colmenero A, Solis-Pacheco RC, Elizondo-Plazas AS, SantosSantillana KM, Gonzalez-Sariñana L, Gonzalez-Nava V, Gonzalez-Gonzalez JG. Hypertriglyceridemia and Its Association with HbA1c Test: A Prospective <i>In Vivo</i> Controlled Study. Int J Endocrinol. 2019 Feb 12;2019:4784313. doi: 10.1155/2019/4784313. PMID: 30891069; PMCID: PMC6390253.
  28. Montes-Villarreal J, Perez-Arredondo LA, Rodriguez-Gutierrez R, GonzalezColmenero AD, Solis RC, González-González JG, Mancillas-Adame LG. SERUM MORNING CORTISOL AS A SCREENING TEST    FOR   ADRENAL INSUFFICIENCY. Endocr Pract. 2020 Jan;26(1):30-35. doi: 10.4158/EP-20190327. Epub 2019 Aug 28. PMID: 31461355.
  29. Álvarez-Villalobos NA, Rodríguez-Gutiérrez R, González-Saldivar G, Sánchez-García A, Gómez-Flores M, Quintanilla-Sánchez C, Treviño-Álvarez AM, Mancillas-Adame LG, González-González JG. Acanthosis nigricans in middle-age adults: A highly prevalent and specific clinical sign of insulin resistance. Int J Clin Pract. 2020 Mar;74(3):e13453. doi: 10.1111/ijcp.13453. Epub 2019 Dec 9. PMID: 31769902.
  30. Alcocer-Gamba MA, Gutiérrez-Fajardo P, Sosa-Caballero A, Cabrera-Rayo A, Faradji-Hazan RN, Padilla-Padilla FG, Garnica-Cuellar JC, Hernández-Arispe LM, Reyes-Cianeros FA, León-Suárez A, de-Jesús-Rivera J, Mancillas-Adame L, Gaxiola-Macias M, Márquez-Rodríguez E, Miranda-Malpica E, Sanchez-Pedraza V, Lara-Martínez DS, Segovia-Palomo A, Nava-Hernández A, Rivera-Reyes R. Recommendations for the care of patients with diabetes mellitus with risk factors or established cardiovascular disease and SARS-CoV-2 mellitus con factores de riesgo ovenfermedad cardiovascular establecida y SARS-CoV-2. Arch Cardiol Mex. 2020;90(Supl):77-83. English. doi: 10.24875/ACM.M20000074. PMID: 32523151.
  31. Sánchez-García A, Rodríguez-Gutiérrez R, Mancillas-Adame L, GonzálezNava V, Díaz González-Colmenero A, Solis RC, Álvarez-Villalobos NA, González-González JG. Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review. Int J Endocrinol. 2020 Mar 10;2020:4678526. doi: 10.1155/2020/4678526. PMID: 32256572; PMCID: PMC7085845.
  32. Sánchez-García A, Rodríguez-Gutiérrez R, Saldívar-Rodríguez D, Guzmán-López A, Castillo-Castro C, Mancillas-Adame L, Santos-Santillana K, GonzálezNava V, González-González JG. Diagnostic accuracy of the triglyceride-glucose index for gestational diabetes screening: a practical approach. Gynecol Endocrinol. 2020 Apr 1:1-4. doi: 10.1080/09513590.2020.1742687. Epub ahead of print. PMID: 32233827.
  33. Sánchez-García A, Rodríguez-Gutiérrez R, Saldívar-Rodríguez D, GuzmánLópez A, Mancillas-Adame L, González-Nava V, Santos-Santillana K, GonzálezGonzález JG. Early triglyceride and glucose index as a risk marker for gestational diabetes mellitus. Int J Gynaecol Obstet. 2020 Jul 17. doi: 10.1002/ijgo.13311. Epub ahead of prin

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